Biointerfaces

Engineered skin commensal nanogels mitigate psoriasiform inflammation through coordinated regulation of cutaneous flora and host immunity.

This review discusses living microorganism-encapsulated hydrogels and their microorganism-material synergy for next-generation therapeutic applications.

This work develops magnetic field-enhanced flexible batteries and vertically integrated actuator-battery-sensor systems for untethered soft robots with embodied intelligence.

Engineered bacterial living biohybrids integrate H2S production and CuS-mediated photothermal therapy for synergistic cancer treatment.

Thermo-responsive fluorosurfactants enable on-demand microfluidic generation and retrieval of cell-laden microgels without harmful demulsifiers.

This work develops 3D MSC exosome-functionalized GelMA hydrogels as a sustained release system for multidimensional corneal wound healing.

Photosynthetic bacteria provide living hydrogen-photothermal therapeutics for synergistic and targeted cancer treatment.

Hydrogels offer a groundbreaking solution for treating chronic inflammatory skin diseases like psoriasis and atopic dermatitis by enhancing drug delivery and minimizing side effects. This review delves into hydrogel design, drug integration, and clinical trial data, highlighting their potential and future opportunities in improving treatment efficacy and safety.

This study demonstrates that a dynamic hydrogel composite can release cellular-size granules in the physiological environments for regenerative medicine and bioelectronics, which has been long sought in the development of hydrogel-based artificial cells21. A monolithic-to-focal evolving process allows the composite to harness the properties and functions of both monolithic and focal biointerfaces. The hydrogel composites use gelatin and chitosan as the hydrogel matrix to respond to biological environments while also facilitating macroscopic material shaping and manipulation.

We designed a soil-inspired chemical system that consists of nanostructured minerals, starch granules and liquid metals. The soil-inspired material possesses chemical, optical and mechanical responsiveness to yield write–erase functions in electrical performance. The composite can also modulate bacterial growth both in vitro and in vivo, such as enriches gut bacteria diversity, rectifies tetracycline-induced gut microbiome dysbiosis and ameliorates dextran sulfate sodium-induced rodent colitis symptoms within rodent models.