We developed a cost-competitive and environmentally friendly approach that is promising for sustainable and scalable production of semiconductor biohybrids towards solar-driven chemical production utilizing multiple pollutants in wastewater. Compared with fossil-fuels refining and sugar-based bacterial fermentation, the wastewater-derived biohybrid system shows lower carbon emission and production cost. We believe wastewater-based hybrid fermentation will provide an alternative for both sustainable biomanufacturing and environmental remediation.