Nanomedicine

Carrier-Free Nanoassembly Suppresses Phase Separation via Ribosome-Inspired Crowding Control for Enhanced Chemo-Immunotherapy
ACS Nano 2026
A carrier-free nanoassembly co-delivers OSI-027 and an SN-38 prodrug to suppress ribosome-driven phase separation, reprogram tumor-associated macrophages, and enhance chemo-immunotherapy in preclinical pancreatic cancer models.
Xiaoguang Wang, Lisha Cai, Xiaoxiao Zheng, Li Zheng, Hao Liu, Baoming Wang, Liqiang Hu, Shangzhi Xie, Shufen Zhang, Xuemei Lu, Jiayan Mao, Yiliang Lin, Xiang Gao, Jian Li, Xiaoling Xu*, Wei Chen*
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Carrier-Free Nanoassembly Suppresses Phase Separation via Ribosome-Inspired Crowding Control for Enhanced Chemo-Immunotherapy